The Manhattan Project was a big deal

Questions:
Q1. The largest U.S. territorial growth by area was the Louisiana Purchase. Which acquisitions were second and third?
Q2. What is the eight-letter science word for an unexpected change in the genetic sequence?
Q3. In which U.S. state did most of the research for the Manhattan Project take place?
Q4. What year did these events all take place:  Sally Ride in space, final episode of M*A*S*H, invasion of Grenada?
Q5. Who was the director of the 1975 blockbuster hit movie “Jaws?”
Both George Washington and Andrew Jackson owned whiskey distilleries. Thomas Jefferson, James Madison and Donald Trump all owned wineries.
The findagrave.com website has the death and burial data on 250 million individuals. It is owned by ancestry.com.
On March 9, 1943, the 40 residents of Hanford, Washington, 200 miles east of Seattle, were given a 30-day eviction notice by the U.S. War Department. Nearly every building in the town was torn down except for the high school. By the summer of 1945, 51,000 people were living in the area as part of the massive Manhattan Project.
There are 2.1 cows for every human in Wyoming. South Dakota has 4.4 cows for every human.
It is very likely that in 5 billion years the sun will expand into a red giant and engulf the Earth.
John Roebling was the designer of the Brooklyn Bridge, but sadly he died before the construction was even started. Thankfully, his son Washington was a trained engineer and got the project going, but he became paralyzed while building the bridge’s towers. With Washington confined to his bed, responsibility for the project fell to his wife Emily. For most of the construction of the Brooklyn Bridge the lead engineer was a woman.
It is a myth that Apollo astronauts ever ate “freeze dried ice cream.” 
After President Teddy Roosevelt had a few unsuccessful days of bear hunting in Mississippi, local residents managed to trap a small black bear and tie it to a tree. When Roosevelt refused to shoot the trapped bear the national newspapers picked up the story, praising him. A New York City toy store owner honored Roosevelt by naming a stuffed animal Teddy’s Bear. The name stuck.
The last time the Liberty Bell was rung was on February 22, 1846, to celebrate Washington’s birthday. It already had a small crack, but on that date the “big crack” appeared.
Answers:
A1. 2: Alaska Purchase - 586,412 miles2, 3: Mexican Cession -  525,000 miles2 (LA Purchase was 828,000 miles2)
A2. Mutation (Over time, mutations can lead to positive or negative adaptations.)
A3. New Mexico (Oak Ridge, Tennessee, Hanford, Washington, U. of Chicago and U.C. Berkley also had facilities.)
A4. 1983 (Also: Korean Air 007 shot down, MLK birthday made federal holiday.)
A5. Steven Spielberg